The Guardians swept their two-game set against the Reds following a 5-2 win from Progressive.
Jose Ramirez blasted the go-ahead, three-run homer in the eighth inning.
Emmanuel Clase notched the save to become the team's all-time saves leader in a season as Cleveland has won five-of-seven and already clinched the AL Central at 92-and-67.
The Guardians host the Astros tomorrow night for their last series of the regular season.