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The Guardians dropped their series to the Cardinals following a 2-1 loss from St. Louis.
Tim Herrin got the loss after giving up the go-ahead run in relief.
Austin Hedges drove in the team's lone run in the sixth inning as the Guardians have lost back-to-back games.
Cleveland already clinched the AL Central at 90-and-67 and will host the Reds tomorrow night.