The Cavaliers fell to the Suns 117-11 at Rocket Mortgage Fieldhouse.
Darius Garland led the team with 39 points, while Caris LeVert sunk 17 and dished out 11 assists.
Jarrett Allen also tallied a double-double on 15 points and 10 rebounds as Cleveland slipped to 41-and-24.
The Cavs are second in the Central Division and will visit the Pelicans tomorrow night.