The Cavaliers fell to the Knicks 107-98 at Rocket Mortgage FieldHouse.
Darius Garland led the starters in scoring with 19 points and dished out five assists.
Sam Merrill paced the team with 21 points off the bench, while Evan Mobley tallied a double-double on 13 points and boards.
The Cavs will host the Celtics tomorrow night.