The Cavaliers snapped the Clippers' winning streak following a 118-108 victory in Cleveland.
Donovan Mitchell led the team in scoring with 28 points and dished out a game-high 12 assists for a double-double.
Jarrett Allen tallied his own with 20 points and a game-high 17 rebounds.
The Cavs sit second in the Central Division at 28-and-16 and will host the Pistons tomorrow night.