Gardner Minshew tossed two first-quarter touchdowns as the Jaguars topped the Titans 20-7 in Jacksonville.
The Jags' defense piled up nine sacks, including three from Calais Campbell and two-and-a-half from rookie Josh Allen.
Jalen Ramsey had nine tackles after requesting a trade earlier in the week as Jacksonville earned its first win in wire-to-wire fashion.
Derrick Henry broke up the shutout with a one-yard TD run in the fourth quarter for Tennessee, which fell to 1-and-2.
An early muffed punt by Adoree Jackson led to a quick Jaguars' touchdown and they never looked back.