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The Tigers shutout the Guardians to take a 2-1 lead in the ALDS.
Detroit topped Cleveland 3-0 in Game Three at Comerica Park.
Alex Cobb was tagged with the loss after allowing two runs on three hits over three innings pitched.
Steven Kwan led the way at the plate after going three for four for the Guardians, who look to avoid elimination when they visit the Tigers for Game Four tonight.