The Browns fell to the Giants 21-15 from Huntington Bank Field.
Deshaun Watson completed 21-of-37 passes for 196 yards and two touchdowns. He also lost a pair of fumbles.
Amari Cooper caught both TD's and finished with 86 yards while Jerome Ford carried the ball 10 times for 37 yards.
The Browns dropped to third in the AFC North at 1-and-2 and will visit the Raiders next Sunday afternoon.