The Guardians lost their series against the Astros following an 8-2 loss in the finale from Houston.
Andres Gimenez and Jose Ramirez drove in the team's only runs in the second inning.
Logan Allen got the loss after giving up two earned runs, while Tyler Beede gave up five runs and recorded just one out in relief.
Cleveland still leads the AL Central at 20-and-11 and will host the Angels for the first of three games tonight.