The Guardians were incredibly rude guests and stifled the Fenway faithful on Patriots' Day in Boston.
Cleveland shutout the Red Sox 6-0 on Marathon Monday.
Will Brennan slugged a pinch-hit, two-run homer in the seventh inning to open the floodgates.
The Guardians remain first in the AL Central at 11-and-5 and will continue the four-game set tonight.